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Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Western blot analysis using PLCG2 mouse mAb against A431 cell lysate.
Immunofluorescence analysis of Hela cells using PLCG2 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)
Flow cytometric analysis of Hela cells using PLCG2 mouse mAb (green) and negative control (red).

Mouse Monoclonal Antibody to PLCG2

  • 货号:

    30725
  • 别名:

    FCAS3; APLAID; PLC-IV; PLC-gamma-2
  • 产品上架时间:

    2024-01-01
  • 应用:

    WB,ICC,FCM
  • 反应种属:

    Human
  • 抗体类型:

    Primary antibody
  • Swissprot:

    P16885
  • 规格:

  • 数量:

    -
    +
  • 说明书:

    目录价¥2180

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Mouse Monoclonal Antibody to PLCG2

Description

The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3.

References

1. Mol Cell Biol. 2011 Mar;31(6):1240-51.
2. Am J Hum Genet. 2012 Oct 5;91(4):713-20.

Specification

Aliases FCAS3; APLAID; PLC-IV; PLC-gamma-2
Entrez GeneID 5336
Swissprot P16885
clone 3A8B6
WB Predicted band size 148kDa
Host/Isotype Mouse IgG2b
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Synthesized peptide of human PLCG2 (AA: phospho-Tyrosine 753 of human Phospholipase Cg2(cERDINSLpYDVSRMYV)).
Formulation Purified antibody in PBS with 0.05% sodium azide.

Application

WB 1/500 - 1/2000
ICC 1/200 - 1/1000
FCM 1/200 - 1/400
ELISA 1/10000