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Mouse Monoclonal Antibody to SNAI1
-
货号:
30145 -
别名:
SNA; SNAH; SLUGH2; dJ710H13.1; SNAI1 -
应用:
WB -
反应种属:
Human -
抗体类型:
Primary antibody -
Swissprot:
O95863 -
规格:
-
数量:
-+ -
说明书:
目录价¥2180

Mouse Monoclonal Antibody to SNAI1
Description |
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Snail is a zinc-finger transcription factor that can repress E-cadherin transcription. Downregulation of E-cadherin is associated with epithelial-mesenchymal transition during embryonic development, a process also exploited by invasive cancer cells . Indeed, loss of E-cadherin expression is correlated with the invasive properties of some tumors and there is a considerable inverse correlation between Snail and E-cadherin mRNA levels in epithelial tumor cell lines . In addition, Snail blocks the cell cycle and confers resistance to cell death . Phosphorylation of Snail by GSK-3 and PAK1 regulates its stability, cellular localization and function .Tissue specificity: Expressed in a variety of tissues with the highest expression in kidney. |
References |
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1. Exp Cell Res. 2008 Aug 1;314(13):2448-53. 2. Mol Cell Biol. 2008 Aug;28(15):4772-81. |
Specification |
|
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Aliases | SNA; SNAH; SLUGH2; dJ710H13.1; SNAI1 |
Entrez GeneID | 6615 |
Swissprot | O95863 |
clone | 6D2 |
WB Predicted band size | 29kDa |
Host/Isotype | Mouse IgG1 |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human |
Immunogen | Purified recombinant fragment of human SNAI1 expressed in E. Coli. |
Formulation | Ascitic fluid containing 0.03% sodium azide. |
Application |
|
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WB | 1/500-1/1000 |
ELISA | 1/10000 |
Product Image
For Reseach Only
Application Key:WB - Western Blot | IHC - Immunohistochemistry | ICC - Immunocytochemistry | FCM - Flow Cytometry | ELISA - Enzyme-linked Immunosorbent Assay | IP - Immunoprecipitation
#30145

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