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Mouse Monoclonal Antibody to CTCF
-
货号:
30149 -
别名:
CTCF -
应用:
WB -
反应种属:
Human,Monkey -
抗体类型:
Primary antibody -
Swissprot:
P49711 -
规格:
-
数量:
-+ -
说明书:
目录价¥2180

Mouse Monoclonal Antibody to CTCF
Description |
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This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors.Tissue specificity: Ubiquitous. Absent in primary spermatocytes. |
References |
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1. J Mol Med. 2008 Sep;86(9):1057-66. 2. J Exp Med. 2008 Apr 14;205(4):785-98. 3. EMBO J. 2008 Feb 20;27(4):654-66. |
Specification |
|
---|---|
Aliases | CTCF |
Entrez GeneID | 10664 |
Swissprot | P49711 |
clone | 1D11 |
WB Predicted band size | 83kDa |
Host/Isotype | Mouse IgG1 |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human,Monkey |
Immunogen | Purified recombinant fragment of human CTCF expressed in E. Coli. |
Formulation | Ascitic fluid containing 0.03% sodium azide. |
Application |
|
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WB | 1/500 - 1/2000 |
ELISA | 1/10000 |
For Reseach Only
Application Key:WB - Western Blot | IHC - Immunohistochemistry | ICC - Immunocytochemistry | FCM - Flow Cytometry | ELISA - Enzyme-linked Immunosorbent Assay | IP - Immunoprecipitation
#30149

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