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Mouse Monoclonal Antibody to FOXD3
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货号:
30141 -
别名:
AIS1; HFH2; Genesis; FOXD3 -
应用:
WB,IHC -
反应种属:
Human,Mouse,Monkey -
抗体类型:
Primary antibody -
Swissprot:
Q9UJU5 -
规格:
-
数量:
-+ -
说明书:
目录价¥2180

Mouse Monoclonal Antibody to FOXD3
Description |
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FoxD3 is a member of the Forkhead Box family and is characterized by a winged-helix DNA-binding structure and the important role it plays in embryonic development . This transcriptional regulator is required for the maintenance of pluripotency in the pre-implantation and peri-implantation stages of mouse embryonic development and is also required for trophoblast formation. FoxD3 is required for the maintenance of the mammalian neural crest; FoxD3(-/-) mouse embryos fail around the time of implantation with loss of neural crest-derived structures. FoxD3 also forms a regulatory network with Oct-4 and NANOG to maintain the pluripotency of ES cells. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. Tissue specificity: Expressed in chronic myeloid leukemia, Jurkat T-cell leukemia and teratocarcinoma cell lines, but not in any other cell lines or normal tissues examined. |
References |
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1. J Neuroimmune Pharmacol. 2009 Mar;4(1):103-15. 2. Nature. 2006 May 18;441(7091):315-21. |
Specification |
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Aliases | AIS1; HFH2; Genesis; FOXD3 |
Entrez GeneID | 27022 |
Swissprot | Q9UJU5 |
clone | 5G9 |
WB Predicted band size | 50kDa |
Host/Isotype | Mouse IgG1 |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human,Mouse,Monkey |
Immunogen | Purified recombinant fragment of human FOXD3 expressed in E. Coli. |
Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
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WB | 1/500 - 1/2000 |
IHC | 1/200 - 1/1000 |
ELISA | 1/10000 |
Product Image
- Western blot analysis using FOXD3 mouse mAb against NTERA-2 (1), HUVE-12 (2), HEK293 (3), Hela (4), Jurkat (5), K562 (6), RAW264.7 (7), NIH/3T3 (8), and COS7 (9) cell lysate.
- Immunohistochemical analysis of paraffin-embedded human lung cancer tissues (left) and ovarian cancer tissues (right) using FOXD3 mouse mAb with DAB staining.
For Reseach Only
Application Key:WB - Western Blot | IHC - Immunohistochemistry | ICC - Immunocytochemistry | FCM - Flow Cytometry | ELISA - Enzyme-linked Immunosorbent Assay | IP - Immunoprecipitation
#30141

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