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Immunofluorescence analysis of A549 (left) and SK-BR-3 (right) cells using CTNNB1 mouse mAb (green). Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye.
Flow cytometric analysis of A549 cells using CTNNB1 mouse mAb (green) and negative control (purple).
Immunohistochemical analysis of paraffin-embedded human Placenta tissues using CTNNB1 mouse mAb
HOT

Mouse Monoclonal Antibody to CTNNB1

  • 货号:

    20412
  • 别名:

    CTNNB; FLJ25606; FLJ37923; DKFZp686D02253; CTNNB1;Beta-catenin
  • 产品上架时间:

    2024-01-01
  • 应用:

    IHC,IF,FCM
  • 反应种属:

    Human
  • 抗体类型:

    Primary antibody
  • Swissprot:

    P35222
  • 规格:

  • 数量:

    -
    +
  • 说明书:

    目录价¥2180

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Mouse Monoclonal Antibody to CTNNB1

Description

The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. The distinct peripheral cytosolic proteins, alpha, beta and gamma catenin (102, 94 and 86 kDa) are found in many tissues and bind to the conserved cytoplasmic tail domain of the cell adhesion cadherins. Catenins link E cadherin to other integral membrane or cytoplasmic proteins and are modulated by Wnt1 proto oncogene. The central core region of beta catenin is involved in mediation of cadherin catenin complex interaction with EGFR. Beta-Catenin-mediated signalling is involved at several stages of vertebrate neural development.

References

1. Cancer Gennet Cytogenet. 2008. 187(1):12-8
2. Hepatobiliary Pancreat Dis Int. 2008. 7(5):490-6
3. J Biol Chem. 1995. 270(10):5549-55
4. EMBO J. 1998. 17(5):137-84

Specification

Aliases CTNNB; FLJ25606; FLJ37923; DKFZp686D02253; CTNNB1;Beta-catenin
Entrez GeneID 1499
Swissprot P35222
clone 4D5
WB Predicted band size 85kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of human CTNNB1 expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.

Application

IHC 1/200 - 1/1000
IF 1/200 - 1/1000
FCM 1/200 - 1/400
ELISA 1/10000