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Mouse Monoclonal Antibody to CD38
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货号:
20413 -
别名:
T10; CD38 -
应用:
IHC -
反应种属:
Human -
抗体类型:
Primary antibody -
Swissprot:
P28907 -
规格:
-
数量:
-+ -
说明书:
目录价¥2180

Mouse Monoclonal Antibody to CD38
Description |
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CD38 is a type II integral membrane glycoprotein which is present on early B and T cell lineages and activated B and T cells but is absent from most mature resting peripheral lymphocytes. CD38 is also found on thymocytes, pre-B cells, germinal center B cells, mitogen-activated T cells, monocytes and Ig-secreting plasma cells. CD38 acts as a NAD glycohydrolase in T lym- phocytes. On hematopoietic cells CD38 induces activation, proliferation, and differentiation of mature T and B cells and mediates apoptosis of myeloid and lymphoid progenitor cells. In addition to acting as a signaling receptor, CD38 is also an enzyme capable of producing several calcium-mobilizing metabo- lites, including cyclic adenosine diphosphate ribose (cADPR). CD38 also plays a role in maintaining survival of an invariant NK T (iNKT) cell subset that preferentially contributes to the maintenance of immunological tolerance. |
References |
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1. Trends Biochem Sci. 1992 Dec;17(12):495. 2. J Cell Biol. 1999 Sep 6;146(5):1161-72. 3. Exp Hematol. 2002 Jun;30(6):582-9. 4. Mol Immunol. 2006 Mar;43(7):1029-39. |
Specification |
|
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Aliases | T10; CD38 |
Entrez GeneID | 952 |
Swissprot | P28907 |
clone | 6E12D4A12 |
WB Predicted band size | 34kDa |
Host/Isotype | Mouse IgG1 |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human |
Immunogen | Purified recombinant fragment of human CD38 expressed in E. Coli. |
Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
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IHC | 1/200 - 1/1000 |
ELISA | 1/10000 |
For Reseach Only
Application Key:WB - Western Blot | IHC - Immunohistochemistry | ICC - Immunocytochemistry | FCM - Flow Cytometry | ELISA - Enzyme-linked Immunosorbent Assay | IP - Immunoprecipitation
#20413

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