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Western blot analysis using KRT15 mouse mAb against A431 cell lysate.
Immunofluorescence analysis of HepG2(left) and PACN-1 (right) cells using KRT15 mouse mAb (green). Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye.
Flow cytometric analysis of PACN-1 cells using KRT15 mouse mAb (green) and negative control (purple).
Immunohistochemical analysis of paraffin-embedded human Tonsil tissues using KRT15 mouse mAb
HOT

Mouse Monoclonal Antibody to KRT15

  • 货号:

    20410
  • 别名:

    K15; CK15; K1CO; KRT1
  • 产品上架时间:

    2024-01-01
  • 应用:

    WB,IHC,IF,FCM
  • 反应种属:

    Human
  • 抗体类型:

    Primary antibody
  • Swissprot:

    P19012
  • 规格:

  • 数量:

    -
    +
  • 说明书:

    目录价¥2180

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Mouse Monoclonal Antibody to KRT15

Description

The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Keratin 15 is a type I keratin without a defined type II partner. Keratin 15 is expressed primarily in the basal keratinocytes of stratified tissues, including the fetal epidermis and fetal nail. Expression of keratin 15 is downregulated in some hyperproliferating situations, such as psoriasis and hypertrophic scars. Because keratinocytes in psoriasis and hypertrophic scars are activated, it is suggested that keratin 15 expression is not compatible with keratinocyte activation and the keratin 15 gene is downregulated to maintain the activated phenotype.

References

1. J Invest Dermatol. 1999. 112(3):362-9
2. Exp Cell Res. 2006. 254(1):80-90
3. Mol Cell Biol. 2000. 24(8):3168-79

Specification

Aliases K15; CK15; K1CO; KRT1
Entrez GeneID 3866
Swissprot P19012
clone 6E7
WB Predicted band size 49kDa
Host/Isotype Mouse IgG2a
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of KRT15 expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide.

Application

IHC 1/200 - 1/1000
IF 1/200 - 1/1000
FCM 1/200 - 1/400
ELISA 1/10000