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Mouse Monoclonal Antibody to Metadherin
-
货号:
20407 -
别名:
3D3; AEG1; LYRIC; MTDH -
应用:
WB,IHC,FCM -
反应种属:
Human -
抗体类型:
Primary antibody -
Swissprot:
Q86UE4 -
规格:
-
数量:
-+ -
说明书:
目录价¥2180

Mouse Monoclonal Antibody to Metadherin
Description |
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Metadherin (Metastasis adhesion protein), also known as MTDH, LYsine-RIch CEACAM1 co-isolated (LYRIC), is a novel protein that localizes with the tight junction proteins ZO-1 and occludin in polarized epithelial cells. At the tight junction, it acts not as a structural component, but is rather recruited during the maturation of the tight junction complex. Metadherin is overexpressed in breast cancer tissue and breast tumor xenografts, while much lower levels are expressed in normal breast tissue. Metadherin binds to lung vasculature, one of the four common sites of breast cancer metastasis, through a C-terminal segment in the extracellular domain; blocking this lung-homing domain with antibodies or inhibiting metadherin with siRNA has been reported to inhibit breast cancer metastasis. |
References |
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1. Cancer Cell. 2004 Apr;5(4):365-74. 2. Exp Cell Res. 2004 Oct 15;300(1):134-48. 3. Cancer Cell. 2009 Jan 6;15(1):9-20. |
Specification |
|
---|---|
Aliases | 3D3; AEG1; LYRIC; MTDH |
Entrez GeneID | 92140 |
Swissprot | Q86UE4 |
clone | 2F11C3 |
WB Predicted band size | 64kDa |
Host/Isotype | Mouse IgG1 |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human |
Immunogen | Purified recombinant fragment of human Metadherin expressed in E. Coli. |
Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
---|---|
WB | 1/500 - 1/2000 |
IHC | 1/200 - 1/1000 |
FCM | 1/200 - 1/400 |
ELISA | 1/10000 |
Product Image
- Western blot analysis using Metadherin mouse mAb against K562 (1), SKBR-3 (2), T47D (3), Hela (4) and MCF-7 (5) cell lysate.
- Flow cytometric analysis of Hela cells using Metadherin mouse mAb (green) and negative control (purple).
- Immunohistochemical analysis of paraffin-embedded human Liver tissues using Metadherin mouse mAb
For Reseach Only
Application Key:WB - Western Blot | IHC - Immunohistochemistry | ICC - Immunocytochemistry | FCM - Flow Cytometry | ELISA - Enzyme-linked Immunosorbent Assay | IP - Immunoprecipitation
#20407

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