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Western blot analysis using JAK3 mouse mAb against Jurkat cell lysate (1).

Confocal Immunofluorescence analysis of Hela (left) and HepG2 (right) cells using JAK3 mouse mAb (green). Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye.

Confocal Immunofluorescence analysis of 3T3-L1 cells using JAK3 mouse mAb (green). Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye.

Flow cytometric analysis of Hela cells using JAK3 mouse mAb (blue) and negative control (red).

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Mouse Monoclonal Antibody to JAK3

货号：
20400
别名：
JAKL; LJAK
产品上架时间：
2024-01-01
应用：
WB,IF,FCM
反应种属：
Human,Mouse
抗体类型：
Primary antibody
Swissprot：
P52333
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥2180

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Mouse Monoclonal Antibody to JAK3

Description
JAK3, Janus kinase 3. It is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease).

Description

JAK3, Janus kinase 3. It is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease).

References
1. J Biol Chem. 1995 Oct 20;270(42):25028-36. 2. Proc Natl Acad Sci U S A. 1994 Jul 5;91(14):6374-8. 3. Leuk Lymphoma. 2002 Dec;43(12):2355-62.

Specification
Aliases	JAKL; LJAK
Entrez GeneID	3718
Swissprot	P52333
clone	5H2
WB Predicted band size	125kDa
Host/Isotype	Mouse IgG1
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Purified recombinant fragment of human JAK3 expressed in E. Coli.
Formulation	Purified antibody in PBS with 0.05% sodium azide.