MUSK[20347]
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Confocal Immunofluorescence analysis of HEK293 cells trasfected with extracellular MUSK (aa24-209)-hIgGFc using MUSK mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.
Immunohistochemical analysis of paraffin-embedded human lung cancer (A), muscles (B) and breast cancer (C) using MUSK mouse mAb with DAB staining.

Mouse Monoclonal Antibody to MUSK

  • 货号:

    20347
  • 别名:

    muscle, skeletal, receptor tyrosine kinase
  • 产品上架时间:

    2024-01-01
  • 应用:

    IHC,IF
  • 反应种属:

    Human
  • 抗体类型:

    Primary antibody
  • Swissprot:

    O15146
  • 规格:

  • 数量:

    -
    +
  • 说明书:

    目录价¥2180

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Mouse Monoclonal Antibody to MUSK

Description

MuSK (for Muscle Specific Kinase) is a receptor tyrosine kinase required for the formation of the neuromuscular junction (NMJ). It induces cellular signaling by causing the addition of phosphate molecules to particular tyrosines on itself, and on proteins which bind the cytoplasmic domain of the receptor. It is activated by a nerve-derived proteoglycan called agrin. During development, the growing end of motor neuron axons secrete a protein called agrin.This protein binds to several receptors on the surface of skeletal muscle. The receptor which seems to be required for formation of the neuromuscular junction (NMJ), which comprises the nerve-muscle synapse is called MuSK. MUSK mutations lead to decreased agrin-dependent AchR aggregation, a critical step in the formation of the neuromuscular junction.

References

1. J Neuroimmunol. 2006 Aug;177(1-2):119-31.
2. Ann N Y Acad Sci. 2008;1132:76-83.

Specification

Aliases muscle, skeletal, receptor tyrosine kinase
Entrez GeneID 4593
Swissprot O15146
clone 10A4
WB Predicted band size 97kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant extracellular fragment of human MUSK (aa24-209) fused with hIgGFc tag expressed in HEK293 cell line.
Formulation Purified antibody in PBS with 0.05% sodium azide.

Application

IHC 1/200 - 1/1000
IF 1/200 - 1/1000
ELISA 1/10000

For Reseach Only

Application Key:WB - Western Blot | IHC - Immunohistochemistry | ICC - Immunocytochemistry | FCM - Flow Cytometry | ELISA - Enzyme-linked Immunosorbent Assay | IP - Immunoprecipitation

#20347