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Mouse Monoclonal Antibody to MAP4K4
-
货号:
20235 -
别名:
HGK; NIK -
应用:
WB,FCM -
反应种属:
Human,Mouse -
抗体类型:
Primary antibody -
Swissprot:
O95819 -
规格:
-
数量:
-+ -
说明书:
目录价¥2180

Mouse Monoclonal Antibody to MAP4K4
Description |
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MAP4K4: mitogen-activated protein kinase kinase kinase kinase 4. The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. |
References |
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1. Mol Cell Biol. 2000 Mar;20(5):1537-45. 2. Curr Biol. 2002 Apr 16;12(8):622-31. 3. J Biol Chem. 2007 Mar 16;282(11):7783-9. |
Specification |
|
---|---|
Aliases | HGK; NIK |
Entrez GeneID | 9448 |
Swissprot | O95819 |
clone | 3C7B5 |
Host/Isotype | Mouse IgG1 |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human,Mouse |
Immunogen | Purified recombinant fragment of MAP4K4 (aa400-500) expressed in E. Coli. |
Formulation | Ascitic fluid containing 0.03% sodium azide. |
Application |
|
---|---|
WB | 1/500 - 1/2000 |
FCM | 1/200 - 1/400 |
ELISA | 1/10000 |
Product Image
- Western blot analysis using MAP4K4 mouse mAb against Jurkat (1),PC-12(2), Jurkat (3) ,HepG2(4) lysate.
- Flow cytometric analysis of NIH3T3 cells using MAP4K4 mouse mAb (green) and negative control (red).
- Flow cytometric analysis of K562 cells using MAP4K4 mouse mAb (green) and negative control (red).
For Reseach Only
Application Key:WB - Western Blot | IHC - Immunohistochemistry | ICC - Immunocytochemistry | FCM - Flow Cytometry | ELISA - Enzyme-linked Immunosorbent Assay | IP - Immunoprecipitation
#20235

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