Mouse Monoclonal Antibody to KARS

Description
KARS: lysyl-tRNA synthetase. Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis.

References
1. J Biol Chem. 2000 Nov 10;275(45):35063-9. 2. J Virol. 2001 Jun;75(11):5043-8. 3. Biochem Biophys Res Commun. 2002 Feb 15;291(1):158-64. 4. Cell. 2004 Oct 15;119(2):195-208.

Specification
Aliases	KRS; KARS2; KIAA0070
Entrez GeneID	3735
Swissprot	Q15046
clone	8G12C1
Host/Isotype	Mouse IgG1
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant fragment of KARS(aa90-174) expressed in E. Coli.
Formulation	Ascitic fluid containing 0.03% sodium azide.

Application
IHC	1/200 - 1/1000
ELISA	1/10000