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Mouse Monoclonal Antibody to BTRC
Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Mouse Monoclonal Antibody to BTRC
Western blot analysis using BTRC mouse mAb against Ramos (1), MCF-7 (2), and K562 (3) cell lysate.
Mouse Monoclonal Antibody to BTRC
Flow cytometric analysis of Hela cells using BTRC mouse mAb (green) and negative control (red).
Mouse Monoclonal Antibody to BTRC
Immunohistochemical analysis of paraffin-embedded human esophageal cancer tissues using BTRC mouse mAb with DAB staining.
Mouse Monoclonal Antibody to BTRC
Immunohistochemical analysis of paraffin-embedded human rectum cancer tissues using BTRC mouse mAb with DAB staining.
Mouse Monoclonal Antibody to BTRC
Mouse Monoclonal Antibody to BTRC
Mouse Monoclonal Antibody to BTRC
Mouse Monoclonal Antibody to BTRC
Mouse Monoclonal Antibody to BTRC

Mouse Monoclonal Antibody to BTRC

  • 货号:

    31253
  • 别名:

    FWD1; FBW1A; FBXW1; bTrCP; FBXW1A; bTrCP1; betaTrCP; BETA-TRCP
  • 产品上架时间:

    2024-01-01
  • 应用:

    WB,IHC,FCM
  • 反应种属:

    Human
  • 抗体类型:

    Primary antibody
  • Swissprot:

    Q9Y297
  • 规格:

  • 数量:

    -
    +
  • 说明书:

    目录价¥2180

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Mouse Monoclonal Antibody to BTRC

Description

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6.

References

1.J Biol Chem. 2014 Nov 7;289(45):31102-10.
2.Genet Mol Res. 2013 Mar 11;12(3):3435-43.

Specification

Aliases FWD1; FBW1A; FBXW1; bTrCP; FBXW1A; bTrCP1; betaTrCP; BETA-TRCP
Entrez GeneID 8945
Swissprot Q9Y297
clone 4C5D8
WB Predicted band size 68.9kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of human BTRC (AA: 24-151) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

WB 1/500 - 1/2000
IHC 1/200 - 1/1000
FCM 1/200 - 1/400
ELISA 1/10000