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Mouse Monoclonal Antibody to CHRNA7
Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Mouse Monoclonal Antibody to CHRNA7
Western blot analysis using CHRNA7 mouse mAb against membrane protein lysate of C6 (1), membrane protein lysate of SK-N-SH (2), C6 (3), and HepG2 (4) cell lysate.
Mouse Monoclonal Antibody to CHRNA7
Flow cytometric analysis of SH-SY5Y cells using CHRNA7 mouse mAb (green) and negative control (red).
Mouse Monoclonal Antibody to CHRNA7
Mouse Monoclonal Antibody to CHRNA7
Mouse Monoclonal Antibody to CHRNA7

Mouse Monoclonal Antibody to CHRNA7

  • 货号:

    31257
  • 别名:

    NACHRA7; CHRNA7-2
  • 产品上架时间:

    2024-01-01
  • 应用:

    WB,FCM
  • 反应种属:

    Human,Rat
  • 抗体类型:

    Primary antibody
  • Swissprot:

    P36544
  • 规格:

  • 数量:

    -
    +
  • 说明书:

    目录价¥2180

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Mouse Monoclonal Antibody to CHRNA7

Description

The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants.

References

1.Neuromolecular Med. 2015 Dec;17(4):423-30.
2.Eur J Hum Genet. 2015 Aug;23(8):1019-24.

Specification

Aliases NACHRA7; CHRNA7-2
Entrez GeneID 1139
Swissprot P36544
clone 7F10F1
WB Predicted band size 56.4kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human,Rat
Immunogen Purified recombinant fragment of human CHRNA7 (AA: extra 52-259) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

WB 1/500 - 1/2000
FCM 1/200 - 1/400
ELISA 1/10000