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Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Flow cytometric analysis of SH-SY5Y cells using GRM3 mouse mAb (green) and negative control (red).
Immunohistochemical analysis of paraffin-embedded human bladder cancer tissues using GRM3 mouse mAb with DAB staining.
Immunohistochemical analysis of paraffin-embedded human stomach cancer tissues using GRM3 mouse mAb with DAB staining.

Mouse Monoclonal Antibody to GRM3

  • 货号:

    31255
  • 别名:

    GLUR3; mGlu3; GPRC1C; MGLUR3
  • 产品上架时间:

    2024-01-01
  • 应用:

    IHC,FCM
  • 反应种属:

    Human
  • 抗体类型:

    Primary antibody
  • Swissprot:

    Q14832
  • 规格:

  • 数量:

    -
    +
  • 说明书:

    目录价¥2180

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Mouse Monoclonal Antibody to GRM3

Description

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.

References

1.Prog Neuropsychopharmacol Biol Psychiatry. 2015 Oct 1;62:14-21.
2.Cell Mol Biol (Noisy-le-grand). 2014 Sep 6;60(2):42-9.

Specification

Aliases GLUR3; mGlu3; GPRC1C; MGLUR3
Entrez GeneID 2913
Swissprot Q14832
clone 6H10C3
WB Predicted band size 99kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of human GRM3 (AA: extra 433-576) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

IHC 1/200 - 1/1000
FCM 1/200 - 1/400
ELISA 1/10000