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Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Immunohistochemical analysis of paraffin-embedded human breast cancer tissues using PTPRC mouse mAb with DAB staining.
Immunohistochemical analysis of paraffin-embedded human esophageal cancer tissues using PTPRC mouse mAb with DAB staining.

Mouse Monoclonal Antibody to PTPRC

  • 货号:

    30588
  • 别名:

    LCA; LY5; B220; CD45; L-CA; T200; CD45R; GP180
  • 产品上架时间:

    2024-01-01
  • 应用:

    IHC
  • 反应种属:

    Human
  • 抗体类型:

    Primary antibody
  • Swissprot:

    P08575
  • 规格:

  • 数量:

    -
    +
  • 说明书:

    目录价¥2180

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Mouse Monoclonal Antibody to PTPRC

Description

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.


References

1. Biochem Biophys Res Commun. 2012 Mar 23;419(4):708-14.
2. Blood. 2009 Jun 4;113(23):5905-10.

Specification

Aliases LCA; LY5; B220; CD45; L-CA; T200; CD45R; GP180
Entrez GeneID 5788
Swissprot P08575
clone 5D3A3
WB Predicted band size 147.3kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of human PTPRC (AA: 928-989) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

IHC 1/200 - 1/1000
ELISA 1/10000