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Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Western blot analysis using RB1 mouse mAb against Jurkat (1) and A431 (2) cell lysate.
Flow cytometric analysis of Jurkat cells using RB1 mouse mAb (green) and negative control (red).

Mouse Monoclonal Antibody to RB1

  • 货号:

    30592
  • 别名:

    RB; pRb; OSRC; pp110; p105-Rb
  • 产品上架时间:

    2024-01-01
  • 应用:

    WB,FCM
  • 反应种属:

    Human
  • 抗体类型:

    Primary antibody
  • Swissprot:

    P06400
  • 规格:

  • 数量:

    -
    +
  • 说明书:

    目录价¥2180

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Mouse Monoclonal Antibody to RB1

Description

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

References

1. Cancer Genet. 2011 Jun;204(6):316-22.
2. J Neuropathol Exp Neurol. 2012 Jan;71(1):83-9.

Specification

Aliases RB; pRb; OSRC; pp110; p105-Rb
Entrez GeneID 5925
Swissprot P06400
clone 2A11D4
WB Predicted band size 106.2kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of human RB1 (AA: 2106-2784) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

WB 1/500 - 1/2000
FCM 1/200 - 1/400
ELISA 1/10000

For Reseach Only

Application Key:WB - Western Blot | IHC - Immunohistochemistry | ICC - Immunocytochemistry | FCM - Flow Cytometry | ELISA - Enzyme-linked Immunosorbent Assay | IP - Immunoprecipitation

#30592