提醒成功
搜索
Mouse Monoclonal Antibody to RB1
-
货号:
30592 -
别名:
RB; pRb; OSRC; pp110; p105-Rb -
产品上架时间:
2024-01-01 -
应用:
WB,FCM -
反应种属:
Human -
抗体类型:
Primary antibody -
Swissprot:
P06400 -
规格:
-
数量:
-+ -
说明书:
目录价¥2180
Mouse Monoclonal Antibody to RB1
Description |
---|
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. |
References |
---|
1. Cancer Genet. 2011 Jun;204(6):316-22. 2. J Neuropathol Exp Neurol. 2012 Jan;71(1):83-9. |
Specification |
|
---|---|
Aliases | RB; pRb; OSRC; pp110; p105-Rb |
Entrez GeneID | 5925 |
Swissprot | P06400 |
clone | 2A11D4 |
WB Predicted band size | 106.2kDa |
Host/Isotype | Mouse IgG1 |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human |
Immunogen | Purified recombinant fragment of human RB1 (AA: 2106-2784) expressed in E. Coli. |
Formulation | Purified antibody in PBS with 0.05% sodium azide |
Application |
|
---|---|
WB | 1/500 - 1/2000 |
FCM | 1/200 - 1/400 |
ELISA | 1/10000 |
Product Image
- Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
- Western blot analysis using RB1 mouse mAb against Jurkat (1) and A431 (2) cell lysate.
- Flow cytometric analysis of Jurkat cells using RB1 mouse mAb (green) and negative control (red).
For Reseach Only
Application Key:WB - Western Blot | IHC - Immunohistochemistry | ICC - Immunocytochemistry | FCM - Flow Cytometry | ELISA - Enzyme-linked Immunosorbent Assay | IP - Immunoprecipitation
#30592
相关产品