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Mouse Monoclonal Antibody to PPM1A
-
货号:
30376 -
别名:
PP2CA; PP2Calpha; PP2C-ALPHA -
应用:
WB,FCM -
反应种属:
Human,Monkey -
抗体类型:
Primary antibody -
Swissprot:
P20265 -
规格:
-
数量:
-+ -
说明书:
目录价¥2180

Mouse Monoclonal Antibody to PPM1A
Description |
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The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. |
References |
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1.Biol Psychiatry. 2011 Feb 15;69(4):360-5. 2.Cell Signal. 2009 Jan;21(1):95-102. |
Specification |
|
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Aliases | PP2CA; PP2Calpha; PP2C-ALPHA |
Entrez GeneID | 5494 |
Swissprot | P20265 |
clone | 7F12H6 |
WB Predicted band size | 42.4kDa |
Host/Isotype | Mouse IgG1 |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human,Monkey |
Immunogen | Purified recombinant fragment of human PPM1A (AA: 202-382) expressed in E. Coli. |
Formulation | Purified antibody in PBS with 0.05% sodium azide |
Application |
|
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WB | 1/500 - 1/2000 |
FCM | 1/200 - 1/400 |
ELISA | 1/10000 |
Product Image
- Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
- Western blot analysis using PPM1A mouse mAb against Jurkat (1), Jurkat (2), A431 (3), HeLa (4), HEK293 (5), Raji (6), MCF-7 (7), and COS7 (8) cell lysate.
- Flow cytometric analysis of HeLa cells using PPM1A mouse mAb (green) and negative control (red).
For Reseach Only
Application Key:WB - Western Blot | IHC - Immunohistochemistry | ICC - Immunocytochemistry | FCM - Flow Cytometry | ELISA - Enzyme-linked Immunosorbent Assay | IP - Immunoprecipitation
#30376

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