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Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);

Immunofluorescence analysis of 3T3-L1 cells using CRK mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.

Flow cytometric analysis of MCF-7 cells using CRK mouse mAb (blue) and negative control (red).

Immunohistochemical analysis of paraffin-embedded human rectum cancer tissues using CRK mouse mAb with DAB staining.

Immunohistochemical analysis of paraffin-embedded human bladder cancer tissues using CRK mouse mAb with DAB staining.

Mouse Monoclonal Antibody to CRK

货号：
30256
别名：
CRKII
产品上架时间：
2024-01-01
应用：
IHC,IF,FCM
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
P46108
规格：

100μl
50μl
20μl
数量：

-

+
说明书：

目录价¥2180

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Mouse Monoclonal Antibody to CRK

Description
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.

Description

This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.

References
1. Seikagaku. 2009 May;81(5):361-76. 2. Mol Cancer Res. 2009 Sep;7(9):1582-92.

Specification
Aliases	CRKII
Entrez GeneID	1398
Swissprot	P46108
clone	3G11C1
WB Predicted band size	42kDa
Host/Isotype	Mouse IgG2b
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant fragment of human CRK expressed in E. Coli.
Formulation	Ascitic fluid containing 0.03% sodium azide.