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Mouse Monoclonal Antibody to CRK
Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);
Mouse Monoclonal Antibody to CRK
Immunofluorescence analysis of 3T3-L1 cells using CRK mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
Mouse Monoclonal Antibody to CRK
Flow cytometric analysis of MCF-7 cells using CRK mouse mAb (blue) and negative control (red).
Mouse Monoclonal Antibody to CRK
Immunohistochemical analysis of paraffin-embedded human rectum cancer tissues using CRK mouse mAb with DAB staining.
Mouse Monoclonal Antibody to CRK
Immunohistochemical analysis of paraffin-embedded human bladder cancer tissues using CRK mouse mAb with DAB staining.
Mouse Monoclonal Antibody to CRK
Mouse Monoclonal Antibody to CRK
Mouse Monoclonal Antibody to CRK
Mouse Monoclonal Antibody to CRK
Mouse Monoclonal Antibody to CRK

Mouse Monoclonal Antibody to CRK

  • 货号:

    30256
  • 别名:

    CRKII
  • 产品上架时间:

    2024-01-01
  • 应用:

    IHC,IF,FCM
  • 反应种属:

    Human
  • 抗体类型:

    Primary antibody
  • Swissprot:

    P46108
  • 规格:

  • 数量:

    -
    +
  • 说明书:

    目录价¥2180

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Mouse Monoclonal Antibody to CRK

Description

This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.

References

1. Seikagaku. 2009 May;81(5):361-76. 
2. Mol Cancer Res. 2009 Sep;7(9):1582-92.

Specification

Aliases CRKII
Entrez GeneID 1398
Swissprot P46108
clone 3G11C1
WB Predicted band size 42kDa
Host/Isotype Mouse IgG2b
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of human CRK expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.

Application

IHC 1/200 - 1/1000
IF/ICC 1/200 - 1/1000
FCM 1/200 - 1/400
ELISA 1/10000