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Immunofluorescence analysis of A549 cells using FAK mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.
Flow cytometric analysis of Raji cells using FAK mouse mAb (green) and negative control (purple).
HOT

Mouse Monoclonal Antibody to FAK

  • 货号:

    30053
  • 别名:

    FAK; FADK; FAK1; FRNK; pp125FAK; PTK2
  • 产品上架时间:

    2024-01-01
  • 应用:

    IF,FCM
  • 反应种属:

    Human
  • 抗体类型:

    Primary antibody
  • Swissprot:

    Q05397
  • 规格:

  • 数量:

    -
    +
  • 说明书:

    目录价¥2180

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Mouse Monoclonal Antibody to FAK

Description

This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. At least four transcript variants encoding four different isoforms have been found for this gene, but the full-length natures of only two of them have been determined. Tissue specificity: Expressed in all organs tested, in lymphoid cell lines, but most abundantly in brain.RD: Focal adhesion kinase 1 (FAK) is a ubiquitously expressed non-receptor protein tyrosine kinase that is concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. This cellular localization is directed by a

References

1. J Biol Chem. 2009 Aug 21;284(34):22865-77.
2. Biochem Biophys Res Commun. 2009 Oct 16;388(2):301-5.

Specification

Aliases FAK; FADK; FAK1; FRNK; pp125FAK; PTK2
Entrez GeneID 5747
Swissprot Q05397
clone 10H7E9
WB Predicted band size 119kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of human FAK expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.

Application

IF 1/200 - 1/1000
FCM 1/200 - 1/400
ELISA 1/10000

For Reseach Only

Application Key:WB - Western Blot | IHC - Immunohistochemistry | ICC - Immunocytochemistry | FCM - Flow Cytometry | ELISA - Enzyme-linked Immunosorbent Assay | IP - Immunoprecipitation

#30053