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Mouse Monoclonal Antibody to IHOG

  • 货号:

    30057
  • 别名:

    CG9211; CT26314; Dmel CG9211; ihog; Ihog
  • 产品上架时间:

    2024-01-01
  • 应用:

  • 反应种属:

    Drosophila Melanogaster
  • 抗体类型:

    Primary antibody
  • Swissprot:

    Q9VM64
  • 规格:

  • 数量:

    -
    +
  • 说明书:

    目录价¥2180

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Mouse Monoclonal Antibody to IHOG

Description

The ihog gene (interference hedgehog), identified by RNA interference in Drosophila cultured cells, encodes a type 1 membrane protein shown here to bind and to mediate response to the active Hedgehog (Hh) protein signal. ihog mutations produce defects characteristic of Hh signaling loss in embryos and imaginal discs, and epistasis analysis places ihog action at or upstream of the negatively acting receptor component, Patched (Ptc). The first of two extracellular fibronectin type III (FNIII) domains of the Ihog protein mediates a specific interaction with Hh protein in vitro, but the second FNIII domain is additionally required for in vivo signaling activity and for Ihog-enhanced binding of Hh protein to cells coexpressing Ptc. Other members of the Ihog family, including Drosophila Boi and mammalian CDO and BOC, also interact with Hh ligands via a specific FNIII domain, thus identifying an evolutionarily conserved family of membrane proteins that function in Hh signal response.

References

1. Cell. 2006 Apr 21;125(2):343-57.
2. Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17208-13.

Specification

Aliases CG9211; CT26314; Dmel CG9211; ihog; Ihog
Entrez GeneID 33972
Swissprot Q9VM64
clone 3G8
WB Predicted band size 98kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Drosophila Melanogaster
Immunogen Purified recombinant fragment of human IHOG expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.

Application

ELISA 1/10000

Product Image

For Reseach Only

Application Key:WB - Western Blot | IHC - Immunohistochemistry | ICC - Immunocytochemistry | FCM - Flow Cytometry | ELISA - Enzyme-linked Immunosorbent Assay | IP - Immunoprecipitation

#30057