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Mouse Monoclonal Antibody to IHOG
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货号:
30057 -
别名:
CG9211; CT26314; Dmel CG9211; ihog; Ihog -
应用:
-
反应种属:
Drosophila Melanogaster -
抗体类型:
Primary antibody -
Swissprot:
Q9VM64 -
规格:
-
数量:
-+ -
说明书:
目录价¥2180

Mouse Monoclonal Antibody to IHOG
Description |
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The ihog gene (interference hedgehog), identified by RNA interference in Drosophila cultured cells, encodes a type 1 membrane protein shown here to bind and to mediate response to the active Hedgehog (Hh) protein signal. ihog mutations produce defects characteristic of Hh signaling loss in embryos and imaginal discs, and epistasis analysis places ihog action at or upstream of the negatively acting receptor component, Patched (Ptc). The first of two extracellular fibronectin type III (FNIII) domains of the Ihog protein mediates a specific interaction with Hh protein in vitro, but the second FNIII domain is additionally required for in vivo signaling activity and for Ihog-enhanced binding of Hh protein to cells coexpressing Ptc. Other members of the Ihog family, including Drosophila Boi and mammalian CDO and BOC, also interact with Hh ligands via a specific FNIII domain, thus identifying an evolutionarily conserved family of membrane proteins that function in Hh signal response. |
References |
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1. Cell. 2006 Apr 21;125(2):343-57. 2. Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17208-13. |
Specification |
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Aliases | CG9211; CT26314; Dmel CG9211; ihog; Ihog |
Entrez GeneID | 33972 |
Swissprot | Q9VM64 |
clone | 3G8 |
WB Predicted band size | 98kDa |
Host/Isotype | Mouse IgG1 |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Drosophila Melanogaster |
Immunogen | Purified recombinant fragment of human IHOG expressed in E. Coli. |
Formulation | Ascitic fluid containing 0.03% sodium azide. |
Application |
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ELISA | 1/10000 |
Product Image
For Reseach Only
Application Key:WB - Western Blot | IHC - Immunohistochemistry | ICC - Immunocytochemistry | FCM - Flow Cytometry | ELISA - Enzyme-linked Immunosorbent Assay | IP - Immunoprecipitation
#30057

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