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Western blot analysis using PYK2 mouse mAb against Raji (1), PMA induced THP-1 (2), Jurkat (3) and Ramos (4) cell lysate.
Immunohistochemical analysis of paraffin-embedded human Tonsil tissues using PYK2 mouse mAb.
HOT

Mouse Monoclonal Antibody to PYK2

  • 货号:

    20212
  • 别名:

    PKB; PTK; CAKB; FAK2; FRNK; PTK2B
  • 产品上架时间:

    2024-01-01
  • 应用:

    WB,IHC
  • 反应种属:

    Human
  • 抗体类型:

    Primary antibody
  • Swissprot:

    Q14289
  • 规格:

  • 数量:

    -
    +
  • 说明书:

    目录价¥2180

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Mouse Monoclonal Antibody to PYK2

Description

PYK2: PTK2B protein tyrosine kinase 2 beta, also known as PTK2B, PKB, PTK, CAKB, FAK2, FRNK. Entrez Protein NP_004094. It is a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.

References

1. Exp Hematol. 2004 Apr;32(4):365-74.
2. J Cell Sci. 2004 May 15;117(Pt 12):2557-68.
3. Int J Cancer. 2005 Feb 20;113(5):689-98.

Specification

Aliases PKB; PTK; CAKB; FAK2; FRNK; PTK2B
Entrez GeneID 2185
Swissprot Q14289
clone 5E2D5
WB Predicted band size 115.8kDa
Host/Isotype Mouse IgG2a
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of PYK2 (aa815-997) expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.

Application

WB 1/500 - 1/2000
IHC 1/200 - 1/1000
ELISA 1/10000

For Reseach Only

Application Key:WB - Western Blot | IHC - Immunohistochemistry | ICC - Immunocytochemistry | FCM - Flow Cytometry | ELISA - Enzyme-linked Immunosorbent Assay | IP - Immunoprecipitation

#20212