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Mouse Monoclonal Antibody to PAR4
-
货号:
20213 -
别名:
PAWR -
应用:
WB,IHC -
反应种属:
Human -
抗体类型:
Primary antibody -
Swissprot:
Q96IZ0 -
规格:
-
数量:
-+ -
说明书:
目录价¥2180

Mouse Monoclonal Antibody to PAR4
Description |
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Prostate apoptosis response 4 (Par4) is a 38kD protein originally identified as the product of a gene that is upregulated in prostate tumor cells undergoing apoptosis. It is a leucine zipper and death domain containing protein whose levels increase in neurons undergoing apoptosis as a result of trophic factor withdrawal or exposure to oxidative and metabolic insults. Par4 levels are reported to be increased in their lumbar spinal cord specimens further suggesting a role in neuronal degeneration. The tumor suppressor WT1 represses and activates transcription. The loss and/or imbalance of the dual transcriptional activity of WT1 may contribute to Wilms tumor. Par4 is a WT1 interacting protein that also functions as a transcriptional repressor. |
References |
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1. J Biol Chem. 2004 Jul 2;279(27):28266-75. 2. Exp Hematol. 2004 Jul;32(7):649-56. 3. Mol Cell Biol. 2005 Feb;25(3):1146-61. 4. Psychiatr Genet. 2006 Oct;16(5):193-6. |
Specification |
|
---|---|
Aliases | PAWR |
Entrez GeneID | 5074 |
Swissprot | Q96IZ0 |
clone | 3G9H7 |
Host/Isotype | Mouse IgG1 |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human |
Immunogen | Purified recombinant fragment of PAR4(aa1-330) expressed in E. Coli. |
Formulation | Ascitic fluid containing 0.03% sodium azide. |
Application |
|
---|---|
WB | 1/500 - 1/2000 |
IHC | 1/200 - 1/1000 |
ELISA | 1/10000 |
Product Image
For Reseach Only
Application Key:WB - Western Blot | IHC - Immunohistochemistry | ICC - Immunocytochemistry | FCM - Flow Cytometry | ELISA - Enzyme-linked Immunosorbent Assay | IP - Immunoprecipitation
#20213

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