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Immunohistochemical analysis of paraffin-embedded human colon cancer (left) and breast cancer (right) showing cytoplasmic localization with DAB staining using FBLN5 mouse mAb.

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Mouse Monoclonal Antibody to FBLN5

货号：
20197
别名：
EVEC; UP50; ARMD3; DANCE
产品上架时间：
2024-01-01
应用：
IHC
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
Q9UBX5
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥2180

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Mouse Monoclonal Antibody to FBLN5

Description
FBLN5: fibulin 5. The protein is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling.

Description

FBLN5: fibulin 5. The protein is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling.

References
1. Am J Hum Genet. 2003 Apr;72(4):998-1004. 2. Genome Res. 2003 Oct;13(10):2265-70 3. N Engl J Med. 2004 Jul 22;351(4):346-53. 4. Surgery. 2005 Aug;138(2):352-9.

Specification
Aliases	EVEC; UP50; ARMD3; DANCE
Entrez GeneID	10516
Swissprot	Q9UBX5
clone	1G6A4
Host/Isotype	Mouse IgG1
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant fragment of FBLN5 (aa242-448) expressed in E. Coli.
Formulation	Purified antibody in PBS with 0.05% sodium azide.