Rabbit Polyclonal Antibody to Phospho-Src (Tyr419)

Description
Src activity is regulated by tyrosine phosphorylation at two sites, but with opposing effects. While phosphorylation at Tyr416 in the activation loop of the kinase domain upregulates enzyme activity, phosphorylation at Tyr527 in the carboxy-terminal tail by Csk renders the enzyme less active (2).

Specification
Aliases	SRC; SRC1; Proto-oncogene tyrosine-protein kinase Src; Proto-oncogene c-Src; pp60c-src; p60-Src
Entrez GeneID	6714
Swissprot	P12931
WB Predicted band size	Calculated MW: 60 kDa; Observed MW: 60 kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	A synthesized peptide derived from human Phospho-Src (Y419)
Formulation	Purified antibody in PBS with 0.05% sodium azide.

Application
WB	1/500-1/1000
FCM	1/50-1/100