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Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)

Immunofluorescence analysis of Hela cells using TIM3 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)

Flow cytometric analysis of Jurkat cells using TIM3 mouse mAb (green) and negative control (red).

Mouse Monoclonal Antibody to TIM3

货号：
31374
别名：
HAVCR2; CD366; KIM-3; TIMD3; Tim-3; TIMD-3; HAVcr-2
产品上架时间：
2024-01-01
应用：
IF,FCM
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
Q8TDQ0
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥2180

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Mouse Monoclonal Antibody to TIM3

Description
The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance.

Description

The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance.

References
1.Tumour Biol. 2016 Jun;37(6):8209-18. 2.Int Immunopharmacol. 2015 Dec;29(2):635-641.

Specification
Aliases	HAVCR2; CD366; KIM-3; TIMD3; Tim-3; TIMD-3; HAVcr-2
Entrez GeneID	84868
Swissprot	Q8TDQ0
clone	7C8A7
WB Predicted band size	33.4kDa
Host/Isotype	Mouse IgG1
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant fragment of human TIM3 (AA: extra 22-202) expressed in HEK293 cells.
Formulation	Purified antibody in PBS with 0.05% sodium azide