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Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Flow cytometric analysis of Jurkat cells using Phospho-4E-BP1 (Ser65) mouse mAb (green) and negative control (red).
Immunohistochemical analysis of paraffin-embedded human stomach cancer tissues using Phospho-4E-BP1 (Ser65) mouse mAb with DAB staining.
Immunohistochemical analysis of paraffin-embedded human rectum cancer tissues using Phospho-4E-BP1 (Ser65) mouse mAb with DAB staining.

Mouse Monoclonal Antibody to Phospho-4E-BP1 (Ser65)

  • 货号:

    31175
  • 别名:

    EIF4EBP1; BP-1; 4EBP1; 4E-BP1; PHAS-I
  • 产品上架时间:

    2024-01-01
  • 应用:

    IHC,FCM
  • 反应种属:

    Human
  • 抗体类型:

    Primary antibody
  • Swissprot:

    Q13541
  • 规格:

  • 数量:

    -
    +
  • 说明书:

    目录价¥2180

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Mouse Monoclonal Antibody to Phospho-4E-BP1 (Ser65)

Description

This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.

References

1.Sci Signal. 2015 Nov 17;8(403):ra116.
2.Oncotarget. 2015 Sep 15;6(27):24092-104.

Specification

Aliases EIF4EBP1; BP-1; 4EBP1; 4E-BP1; PHAS-I
Entrez GeneID 1978
Swissprot Q13541
clone 2D1G11
WB Predicted band size 12.6kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Synthesized peptide of human Phospho-4E-BP1 (Ser65).
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

IHC 1/200 - 1/1000
FCM 1/200 - 1/400
ELISA 1/10000