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Mouse Monoclonal Antibody to PRKAA2
Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Mouse Monoclonal Antibody to PRKAA2
Western blot analysis using PRKAA2 mouse mAb against HEK293 (1) and COS7 (2) cell lysate.
Mouse Monoclonal Antibody to PRKAA2
Western blot analysis using PRKAA2 mouse mAb against Mouse liver(1)PC-12(2)NIH/3T3(3)NRK(4)C2C12(5)C6(6)cell lysate.
Mouse Monoclonal Antibody to PRKAA2
Immunofluorescence analysis of NIH/3T3 cells using PRKAA2 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
Mouse Monoclonal Antibody to PRKAA2
Flow cytometric analysis of Jurkat cells using PRKAA2 mouse mAb (green) and negative control (red).
Mouse Monoclonal Antibody to PRKAA2
Immunohistochemical analysis of paraffin-embedded human stomach cancer tissues using PRKAA2 mouse mAb with DAB staining.
Mouse Monoclonal Antibody to PRKAA2
Immunohistochemical analysis of paraffin-embedded human rectum cancer tissues using PRKAA2 mouse mAb with DAB staining.
Mouse Monoclonal Antibody to PRKAA2
Immunohistochemical analysis of paraffin-embedded Mouse kidney using PRKAA2 mouse mAb with DAB staining.
Mouse Monoclonal Antibody to PRKAA2
Immunohistochemical analysis of paraffin-embedded Rat kidney using PRKAA2 mouse mAb with DAB staining.
Mouse Monoclonal Antibody to PRKAA2
Immunohistochemical analysis of paraffin-embedded Rabbit kidney using PRKAA2 mouse mAb with DAB staining.
Mouse Monoclonal Antibody to PRKAA2
Mouse Monoclonal Antibody to PRKAA2
Mouse Monoclonal Antibody to PRKAA2
Mouse Monoclonal Antibody to PRKAA2
Mouse Monoclonal Antibody to PRKAA2
Mouse Monoclonal Antibody to PRKAA2
Mouse Monoclonal Antibody to PRKAA2
Mouse Monoclonal Antibody to PRKAA2
Mouse Monoclonal Antibody to PRKAA2
Mouse Monoclonal Antibody to PRKAA2

Mouse Monoclonal Antibody to PRKAA2

  • 货号:

    31178
  • 别名:

    AMPK; AMPK2; PRKAA; AMPKa2
  • 产品上架时间:

    2024-01-01
  • 应用:

    WB,IHC,IF,FCM
  • 反应种属:

    Human,Mouse,Rat,Monkey,Rabbit
  • 抗体类型:

    Primary antibody
  • Swissprot:

    P54646
  • 规格:

  • 数量:

    -
    +
  • 说明书:

    目录价¥2180

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Mouse Monoclonal Antibody to PRKAA2

Description

The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.

References

1.Pathobiology. 2015;82(5):203-11.
2.Acta Crystallogr D Biol Crystallogr. 2011 May;67(Pt 5):480-7.

Specification

Aliases AMPK; AMPK2; PRKAA; AMPKa2
Entrez GeneID 5563
Swissprot P54646
clone 8E11H5
WB Predicted band size 62.3kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human,Mouse,Rat,Monkey,Rabbit
Immunogen Purified recombinant fragment of human PRKAA2 (AA: 453-552) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

WB 1/500 - 1/2000
IHC 1/100 - 1/500
IF/ICC 1/50 - 1/500
FCM 1/200 - 1/400
ELISA 1/10000