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Mouse Monoclonal Antibody to UHRF1
Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Mouse Monoclonal Antibody to UHRF1
Western blot analysis using UHRF1 mouse mAb against MCF-7 (1), HCT116 (2), HL-60 (3), Hela (4), and HEK293 (5) cell lysate.
Mouse Monoclonal Antibody to UHRF1
Immunohistochemical analysis of paraffin-embedded human esophageal cancer tissues using UHRF1 mouse mAb with DAB staining.
Mouse Monoclonal Antibody to UHRF1
Mouse Monoclonal Antibody to UHRF1
Mouse Monoclonal Antibody to UHRF1

Mouse Monoclonal Antibody to UHRF1

  • 货号:

    31124
  • 别名:

    Np95; hNP95; ICBP90; RNF106; TDRD22; hUHRF1; huNp95
  • 产品上架时间:

    2024-01-01
  • 应用:

    WB,IHC
  • 反应种属:

    Human
  • 抗体类型:

    Primary antibody
  • Swissprot:

    Q96T88
  • 规格:

  • 数量:

    -
    +
  • 说明书:

    目录价¥2180

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Mouse Monoclonal Antibody to UHRF1

Description

This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12.

References

1.Biomarkers. 2015;20(3):183-8.
2.Med Oncol. 2013 Dec;30(4):613.

Specification

Aliases Np95; hNP95; ICBP90; RNF106; TDRD22; hUHRF1; huNp95
Entrez GeneID 29128
Swissprot Q96T88
clone 2A8C7
WB Predicted band size 89.8kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of human UHRF1 (AA: 616-755) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

WB 1/500 - 1/2000
IHC 1/200 - 1/1000
ELISA 1/10000