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Mouse Monoclonal Antibody to TRAF2
-
货号:
31045 -
别名:
TRAP; TRAP3; MGC:45012 -
应用:
WB,FCM -
反应种属:
Human -
抗体类型:
Primary antibody -
Swissprot:
Q12933 -
规格:
-
数量:
-+ -
说明书:
目录价¥2180

Mouse Monoclonal Antibody to TRAF2
Description |
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The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined. |
References |
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1.J Virol. 2014 Apr;88(7):3664-77. 2.Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2011 Nov;27(11):1176-9. |
Specification |
|
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Aliases | TRAP; TRAP3; MGC:45012 |
Entrez GeneID | 7186 |
Swissprot | Q12933 |
clone | 4A12D9 |
WB Predicted band size | 55.8kDa |
Host/Isotype | Mouse IgG2b |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human |
Immunogen | Purified recombinant fragment of human TRAF2 (AA: 39-188) expressed in E. Coli. |
Formulation | Purified antibody in PBS with 0.05% sodium azide |
Application |
|
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WB | 1/500 - 1/2000 |
FCM | 1/200 - 1/400 |
ELISA | 1/10000 |
Product Image
- Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
- Western blot analysis using TRAF2 mouse mAb against MCF-7 (1), A431 (2), Hela (3), Jurkat (4), HEK293 (5), and Ramos (6) cell lysate.
- Flow cytometric analysis of Hela cells using TRAF2 mouse mAb (green) and negative control (red).
For Reseach Only
Application Key:WB - Western Blot | IHC - Immunohistochemistry | ICC - Immunocytochemistry | FCM - Flow Cytometry | ELISA - Enzyme-linked Immunosorbent Assay | IP - Immunoprecipitation
#31045

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