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Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Western blot analysis using PSMC3 mouse mAb against COS7 (1), C6 (2), Hela (3), and A431 (4) cell lysate.;COS7,C6,Hela,A431
Immunofluorescence analysis of MCF-7 cells using PSMC3 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)
Flow cytometric analysis of Hela cells using PSMC3 mouse mAb (green) and negative control (red).
Immunohistochemical analysis of paraffin-embedded human lung cancer tissues using PSMC3 mouse mAb with DAB staining.
Immunohistochemical analysis of paraffin-embedded human breast cancer tissues using PSMC3 mouse mAb with DAB staining.

Mouse Monoclonal Antibody to PSMC3

  • 货号:

    31040
  • 别名:

    TBP1
  • 产品上架时间:

    2024-01-01
  • 应用:

    WB,IHC,ICC,FCM
  • 反应种属:

    Human,Rat,Monkey
  • 抗体类型:

    Primary antibody
  • Swissprot:

    P17980
  • 规格:

  • 数量:

    -
    +
  • 说明书:

    目录价¥2180

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Mouse Monoclonal Antibody to PSMC3

Description

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9.

References

1.Oncogene. 2012 Apr 5;31(14):1817-24.
2.PLoS One. 2011;6(10):e22800.

Specification

Aliases TBP1
Entrez GeneID 5702
Swissprot P17980
clone 1G10B7
WB Predicted band size 49kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human,Rat,Monkey
Immunogen Purified recombinant fragment of human PSMC3 (AA: 53-152) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

WB 1/500 - 1/2000
IHC 1/200 - 1/1000
ICC 1/200 - 1/1000
FCM 1/200 - 1/400
ELISA 1/10000