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Mouse Monoclonal Antibody to PSMC3
Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Mouse Monoclonal Antibody to PSMC3
Western blot analysis using PSMC3 mouse mAb against COS7 (1), C6 (2), Hela (3), and A431 (4) cell lysate.;COS7,C6,Hela,A431
Mouse Monoclonal Antibody to PSMC3
Immunofluorescence analysis of MCF-7 cells using PSMC3 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)
Mouse Monoclonal Antibody to PSMC3
Flow cytometric analysis of Hela cells using PSMC3 mouse mAb (green) and negative control (red).
Mouse Monoclonal Antibody to PSMC3
Immunohistochemical analysis of paraffin-embedded human lung cancer tissues using PSMC3 mouse mAb with DAB staining.
Mouse Monoclonal Antibody to PSMC3
Immunohistochemical analysis of paraffin-embedded human breast cancer tissues using PSMC3 mouse mAb with DAB staining.
Mouse Monoclonal Antibody to PSMC3
Mouse Monoclonal Antibody to PSMC3
Mouse Monoclonal Antibody to PSMC3
Mouse Monoclonal Antibody to PSMC3
Mouse Monoclonal Antibody to PSMC3
Mouse Monoclonal Antibody to PSMC3

Mouse Monoclonal Antibody to PSMC3

  • 货号:

    31040
  • 别名:

    TBP1
  • 产品上架时间:

    2024-01-01
  • 应用:

    WB,IHC,IF,FCM
  • 反应种属:

    Human,Rat,Monkey
  • 抗体类型:

    Primary antibody
  • Swissprot:

    P17980
  • 规格:

  • 数量:

    -
    +
  • 说明书:

    目录价¥2180

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Mouse Monoclonal Antibody to PSMC3

Description

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9.

References

1.Oncogene. 2012 Apr 5;31(14):1817-24.
2.PLoS One. 2011;6(10):e22800.

Specification

Aliases TBP1
Entrez GeneID 5702
Swissprot P17980
clone 1G10B7
WB Predicted band size 49kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human,Rat,Monkey
Immunogen Purified recombinant fragment of human PSMC3 (AA: 53-152) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

WB 1/500 - 1/2000
IHC 1/200 - 1/1000
IF/ICC 1/200 - 1/1000
FCM 1/200 - 1/400
ELISA 1/10000