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Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Immunofluorescence analysis of HeLa cells using HDAC4 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)
Flow cytometric analysis of HeLa cells using HDAC4 mouse mAb (green) and negative control (red).

Mouse Monoclonal Antibody to HDAC4

  • 货号:

    30872
  • 别名:

    HD4; AHO3; BDMR; HDACA; HA6116; HDAC-4; HDAC-A
  • 产品上架时间:

    2024-01-01
  • 应用:

    ICC,FCM
  • 反应种属:

    Human
  • 抗体类型:

    Primary antibody
  • Swissprot:

    P56524
  • 规格:

  • 数量:

    -
    +
  • 说明书:

    目录价¥2180

加入购物车

Mouse Monoclonal Antibody to HDAC4

Description

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.

References

1.Cancer Res. 2013 Feb 15;73(4):1386-99.
2.Am J Hum Genet. 2010 Aug 13;87(2):219-28.

Specification

Aliases HD4; AHO3; BDMR; HDACA; HA6116; HDAC-4; HDAC-A
Entrez GeneID 9759
Swissprot P56524
clone 7E2E6
WB Predicted band size 119kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of human HDAC4 (AA: 456-592) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

ICC 1/200 - 1/1000
FCM 1/200 - 1/400
ELISA 1/10000