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Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Flow cytometric analysis of Hela cells using WT1 mouse mAb (green) and negative control (red).

Mouse Monoclonal Antibody to WT1

  • 货号:

    30712
  • 别名:

    GUD; AWT1; WAGR; WT33; NPHS4; WIT-2; EWS-WT1
  • 产品上架时间:

    2024-01-01
  • 应用:

    FCM
  • 反应种属:

    Human
  • 抗体类型:

    Primary antibody
  • Swissprot:

    P19544
  • 规格:

  • 数量:

    -
    +
  • 说明书:

    目录价¥2180

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Mouse Monoclonal Antibody to WT1

Description

This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilm's tumors. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation site upstream of and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated.

References

1. Leuk Res. 2013 Oct;37(10):1341-9.
2. Pediatr Blood Cancer. 2013 Aug;60(8):1388-9.

Specification

Aliases GUD; AWT1; WAGR; WT33; NPHS4; WIT-2; EWS-WT1
Entrez GeneID 7490
Swissprot P19544
clone 5G11A5
WB Predicted band size 49.2kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of human WT1 (AA: 314-479) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide.

Application

FCM 1/200 - 1/400
ELISA 1/10000

For Reseach Only

Application Key:WB - Western Blot | IHC - Immunohistochemistry | ICC - Immunocytochemistry | FCM - Flow Cytometry | ELISA - Enzyme-linked Immunosorbent Assay | IP - Immunoprecipitation

#30712