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Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Immunofluorescence analysis of A431 cells using APP mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)

Mouse Monoclonal Antibody to APP

  • 货号:

    30660
  • 别名:

    AAA; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; CTFgamma
  • 产品上架时间:

    2024-01-01
  • 应用:

    IF
  • 反应种属:

    Human
  • 抗体类型:

    Primary antibody
  • Swissprot:

    P05067
  • 规格:

  • 数量:

    -
    +
  • 说明书:

    目录价¥2180

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Mouse Monoclonal Antibody to APP

Description

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

References

1. J Alzheimers Dis. 2013;35(2):285-95.
2. Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):E2077-82.

Specification

Aliases AAA; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; CTFgamma
Entrez GeneID 351
Swissprot P05067
clone 3F12F6
WB Predicted band size 87kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of human APP (AA: 483-699) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide.

Application

IF 1/200 - 1/1000
ELISA 1/10000