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Mouse Monoclonal Antibody to RELB
Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Mouse Monoclonal Antibody to RELB
Immunofluorescence analysis of MCF-7 cells using RELB mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Secondary antibody from Fisher (Cat#: 35503)
Mouse Monoclonal Antibody to RELB
Flow cytometric analysis of MCF-7 cells using RELB mouse mAb (green) and negative control (red).
Mouse Monoclonal Antibody to RELB
Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues using RELB mouse mAb with DAB staining.
Mouse Monoclonal Antibody to RELB
Immunohistochemical analysis of paraffin-embedded human rectum cancer tissues using RELB mouse mAb with DAB staining.
Mouse Monoclonal Antibody to RELB
Mouse Monoclonal Antibody to RELB
Mouse Monoclonal Antibody to RELB
Mouse Monoclonal Antibody to RELB
Mouse Monoclonal Antibody to RELB

Mouse Monoclonal Antibody to RELB

  • 货号:

    30663
  • 别名:

    IREL; I-REL; REL-B
  • 产品上架时间:

    2024-01-01
  • 应用:

    IHC,IF,FCM
  • 反应种属:

    Human
  • 抗体类型:

    Primary antibody
  • Swissprot:

    Q01201
  • 规格:

  • 数量:

    -
    +
  • 说明书:

    目录价¥2180

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Mouse Monoclonal Antibody to RELB

Description

NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment

References

1. BMC Med Genomics. 2010 Nov 10;3:53.
2. Cancer Res. 2009 Apr 15;69(8):3267-71.

Specification

Aliases IREL; I-REL; REL-B
Entrez GeneID 5971
Swissprot Q01201
clone 2E4B1
WB Predicted band size 62.1kDa
Host/Isotype Mouse IgG2a
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of human RELB (AA: 273-443) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide.

Application

IHC 1/200 - 1/1000
IF/ICC 1/200 - 1/1000
FCM 1/200 - 1/400
ELISA 1/10000