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Dot blot analysis of anti-TSC2-pS664 Phospho-specific Pab (Cat.#P30300) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.

Confocal immunofluorescent analysis of Phospho-TSC2-pS664 Antibody(Cat#P30300) with MCF-7 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red).

Rabbit Polyclonal Antibody to Phospho-TSC2(S664)

货号：
P30300
别名：
Tuberin, Tuberous sclerosis 2 protein, TSC2, TSC4
产品上架时间：
2024-01-01
应用：
WB,IF
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
P49815
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥2180

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Rabbit Polyclonal Antibody to Phospho-TSC2(S664)

Description
Mutations in TSC2 lead to tuberous sclerosis complex. The protein is believed to be a tumor suppressor and is able to specifically stimulate the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. TSC2 may have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking.

Description

Mutations in TSC2 lead to tuberous sclerosis complex. The protein is believed to be a tumor suppressor and is able to specifically stimulate the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. TSC2 may have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking.

Specification
Aliases	Tuberin, Tuberous sclerosis 2 protein, TSC2, TSC4
Entrez GeneID	7249
Swissprot	P49815
WB Predicted band size	200.6kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This TSC2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S664 of human TSC2.
Formulation	Purified antibody in PBS with 0.05% sodium azide.