Rabbit Polyclonal Antibody to MMP12

Description
MMP-12 lacks a transmembrane domain and furin cleavage site. The zymogen for MMP-12 is about 54 kDa, and is quickly activated to the 45 kDa form, and this breaks down to cascade of active forms, ending with the common 22 kDa form.Stimulated macrophages produce MMP-12; it has also been found in osteosarcoma cells, synovial fibroblasts and lung fibroblasts.

Specification
Aliases	Macrophage metalloelastase; MME; 3.4.24.65; Macrophage elastase; ME; hME; Matrix metalloproteinase-12; MMP-12; MMP12; HME
Entrez GeneID	4321
Swissprot	P39900
WB Predicted band size	Calculated MW: 54 kDa; Observed MW: 54,45,22 kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	A synthesized peptide derived from human MMP12
Formulation	Purified antibody in PBS with 0.05% sodium azide.

Application
WB	1/500-1/1000