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Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);

Western blot analysis using C-CBL mouse mAb against RAJI (1), RAW264.7 (2), K562 (3), SKBR-3 (4), 3T3-L1 (5), THP-1 (6) and PC-12 (7) cell lysate.

Western blot analysis using C-CBL mouse mAb against PC-12(1)Raw264.7(2)NIH/3T3(3)NRK(4)C2C12(5)C6(6)F9(7)COS-7(8) cell lysate.

Immunofluorescence analysis of Hela cells using C-CBL mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.

Immunofluorescence analysis of COS7 cells using C-CBL mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.

Immunofluorescence analysis of PC-12 cells using C-CBL mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.

Immunofluorescence analysis of NIH/3T3 cells using C-CBL mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.

Flow cytometric analysis of MCF-7 cells using C-CBL mouse mAb (blue) and negative control (red).

Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissues using C-CBL mouse mAb with DAB staining.

Immunohistochemical analysis of paraffin-embedded human bladder cancer tissues using C-CBL mouse mAb with DAB staining.

Immunohistochemical analysis of paraffin-embedded Mouse kidney using C-CBL mouse mAb with DAB staining.

Immunohistochemical analysis of paraffin-embedded Rat kidney using C-CBL mouse mAb with DAB staining.

Immunohistochemical analysis of paraffin-embedded Rabbit kidney using C-CBL mouse mAb with DAB staining.

Mouse Monoclonal Antibody to C-CBL

货号：
30250
别名：
CBL; CBL2; NSLL; C-CBL; RNF55
产品上架时间：
2024-01-01
应用：
WB,IHC,IF,FCM
反应种属：
Human,Mouse,Rat,Monkey,Rabbit
抗体类型：
Primary antibody
Swissprot：
P22681
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥2180

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Mouse Monoclonal Antibody to C-CBL

Description
The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation.

Description

The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation.

References
1. Blood. 2009 Aug 27;114(9):1859-63. 2. Cell Res. 2009 Aug;19(8):950-61. 3. Nature. 2009 Aug 13;460(7257):904-8.

Specification
Aliases	CBL; CBL2; NSLL; C-CBL; RNF55
Entrez GeneID	867
Swissprot	P22681
clone	3B12
WB Predicted band size	120kDa
Host/Isotype	Mouse IgG1
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat,Monkey,Rabbit
Immunogen	Purified recombinant fragment of human C-CBL expressed in E. Coli.
Formulation	Purified antibody in PBS with 0.05% sodium azide.