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Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);
Flow cytometric analysis of HepG2 cells using ApoE mouse mAb (green) and negative control (purple).
Immunohistochemical analysis of paraffin-embedded human liver cancer tissues (left) and brain tissues (right) using ApoE mouse mAb with DAB staining.
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Mouse Monoclonal Antibody to ApoE

  • 货号:

    30215
  • 别名:

    AD2; LPG; LDLCQ5; MGC1571
  • 产品上架时间:

    2024-01-01
  • 应用:

    IHC,FCM
  • 反应种属:

    Human
  • 抗体类型:

    Primary antibody
  • Swissprot:

    P02649
  • 规格:

  • 数量:

    -
    +
  • 说明书:

    目录价¥2180

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Mouse Monoclonal Antibody to ApoE

Description

Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. Tissue specificity: Occurs in all lipoprotein fractions in plasma. It constitutes 10-20% of very low density lipoproteins (VLDL) and 1-2% of high density lipoproteins (HDL). APOE is produced in most organs. Significant quantities are produced in liver, brain, spleen, lung, adrenal, ovary, kidney and muscle.

References

1. Arch Dermatol Res. 2009 Jul;301(6):405-10.
2. Pharmacogenomics J. 2009 Aug;9(4):248-57.

Specification

Aliases AD2; LPG; LDLCQ5; MGC1571
Entrez GeneID 348
Swissprot P02649
clone 1H4
WB Predicted band size 36kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of human ApoE expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide.

Application

IHC 1/200 - 1/1000
FCM 1/200 - 1/400
ELISA 1/10000