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Western blot analysis using CSK mouse mAb against NIH/3T3 (1)Hela (2)COS7 (3), Jurkat (4), Raw246.7 (5), A549 (6), HL-60 (7) and PC-12 (8) cell lysate.

Immunofluorescence analysis of U251 cells using CSK mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.

Flow cytometric analysis of HL-60 cells using CSK mouse mAb (green) and negative control (purple).

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Mouse Monoclonal Antibody to CSK

货号：
30117
别名：
MGC117393; CSK
产品上架时间：
2024-01-01
应用：
WB,IF,FCM
反应种属：
Human,Mouse,Monkey,Rat
抗体类型：
Primary antibody
Swissprot：
P41240
规格：

100μl
50μl
20μl
数量：

-

+
说明书：

目录价¥2180

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Mouse Monoclonal Antibody to CSK

Description
Carboxy-terminal Src kinase (Csk) is a ubiquitously expressed nonreceptor tyrosine kinase that negatively regulates the Src family kinases (SFK) by phosphorylation of the SFK carboxy-terminal tyrosine. Phosphorylated carboxy-terminal tyrosine binds to the SH2 domain of SFK intramolecularly and leads to folding and inactivation of the SFK . This Csk-catalyzed SFK tyrosine phosphorylation is highly specific and exclusive. The SFK carboxy-terminal tyrosine is the only known physiological substrate of Csk .Tissue specificity: Expressed in lung and macrophages.

Description

Carboxy-terminal Src kinase (Csk) is a ubiquitously expressed nonreceptor tyrosine kinase that negatively regulates the Src family kinases (SFK) by phosphorylation of the SFK carboxy-terminal tyrosine. Phosphorylated carboxy-terminal tyrosine binds to the SH2 domain of SFK intramolecularly and leads to folding and inactivation of the SFK . This Csk-catalyzed SFK tyrosine phosphorylation is highly specific and exclusive. The SFK carboxy-terminal tyrosine is the only known physiological substrate of Csk .Tissue specificity: Expressed in lung and macrophages.

References
1. Nat Genet. 2009 Jun;41(6):677-87. 2. Leuk Res. 2009 Sep;33(9):e168-9. 3. J Hypertens. 2011 Jan;29(1):62-9.

Specification
Aliases	MGC117393; CSK
Entrez GeneID	1445
Swissprot	P41240
clone	5F3
WB Predicted band size	50kDa
Host/Isotype	Mouse IgG1
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Monkey,Rat
Immunogen	Purified recombinant fragment of human CSK expressed in E. Coli.
Formulation	Purified antibody in PBS with 0.05% sodium azide.