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Western blot analysis using SMAD4 mouse mAb against A431 (1), SK-N-SH (2), K562 (3), HepG2 (4) and HUVE12 (5) cell lysate.

Immunofluorescence analysis of NIH/3T3 cells using SMAD4 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.

Flow cytometric analysis of K562 cells using SMAD4 mouse mAb (green) and negative control (purple).

Immunohistochemical analysis of paraffin-embedded human lung cancer tissues using SMAD4 mouse mAb with DAB staining.

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Mouse Monoclonal Antibody to SMAD4

货号：
30091
别名：
JIP; DPC4; MADH4; SMAD4
产品上架时间：
2024-01-01
应用：
WB,IHC,IF,FCM
反应种属：
Human,Mouse
抗体类型：
Primary antibody
Swissprot：
Q13485
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥2180

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Mouse Monoclonal Antibody to SMAD4

Description
Common mediator of signal transduction by TGF-beta (transforming growth factor) superfamily; SMAD4 is the common SMAD (co-SMAD). Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. May act as a tumor suppressor Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.

Description

Common mediator of signal transduction by TGF-beta (transforming growth factor) superfamily; SMAD4 is the common SMAD (co-SMAD). Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. May act as a tumor suppressor Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.

References
1. Am J Hum Genet. 2009 Nov;85(5):628-42. 2. Mol Endocrinol. 2010 Mar;24(3):540-51.

Specification
Aliases	JIP; DPC4; MADH4; SMAD4
Entrez GeneID	4089
Swissprot	Q13485
clone	4G1C6
WB Predicted band size	65kDa
Host/Isotype	Mouse IgG1
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Purified recombinant fragment of human SMAD4 expressed in E. Coli.
Formulation	Purified antibody in PBS with 0.05% sodium azide.