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Mouse Monoclonal Antibody to CDKN1B

  • 货号:

    30044
  • 别名:

    KIP1; MEN4; CDKN4; MEN1B; P27KIP1; CDKN1B
  • 产品上架时间:

    2024-01-01
  • 应用:

  • 反应种属:

    Human
  • 抗体类型:

    Primary antibody
  • Swissprot:

    P46527
  • 规格:

  • 数量:

    -
    +
  • 说明书:

    目录价¥2180

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Mouse Monoclonal Antibody to CDKN1B

Description

p27 KIP 1 is a cell cycle regulatory mitotic inhibitor of cdk activity. p27 KIP 1 is a candidate tumor suppressor gene, and has been proposed to function as a possible mediator of TGF beta induced G1 arrest. p27 KIP 1 is up regulated in response to antimitogenic stimuli. The increased protein expression of p27 results in cellular arrest by binding to cyclin/Cdk complexes such as cyclin D1/Cdk4. Decreased levels of p27Kip1, mainly due to proteosomal degradation, are found in various epithelial tumors originating from lung, breast, colon, ovary, esophagus, thyroid and prostate.Tissue specificity: Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney.

References

1. Exp Mol Med. 2009 Nov 30;41(11):765-71.
2. Int J Gynecol Pathol. 2010 Jan;29(1):8-18.

Specification

Aliases KIP1; MEN4; CDKN4; MEN1B; P27KIP1; CDKN1B
Entrez GeneID 1027
Swissprot P46527
clone 3D8
WB Predicted band size 22kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of human CDKN1B expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.

Application

ELISA 1/10000

Product Image

For Reseach Only

Application Key:WB - Western Blot | IHC - Immunohistochemistry | ICC - Immunocytochemistry | FCM - Flow Cytometry | ELISA - Enzyme-linked Immunosorbent Assay | IP - Immunoprecipitation

#30044