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Mouse Monoclonal Antibody to CDKN1B
-
货号:
30044 -
别名:
KIP1; MEN4; CDKN4; MEN1B; P27KIP1; CDKN1B -
应用:
-
反应种属:
Human -
抗体类型:
Primary antibody -
Swissprot:
P46527 -
规格:
-
数量:
-+ -
说明书:
目录价¥2180

Mouse Monoclonal Antibody to CDKN1B
Description |
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p27 KIP 1 is a cell cycle regulatory mitotic inhibitor of cdk activity. p27 KIP 1 is a candidate tumor suppressor gene, and has been proposed to function as a possible mediator of TGF beta induced G1 arrest. p27 KIP 1 is up regulated in response to antimitogenic stimuli. The increased protein expression of p27 results in cellular arrest by binding to cyclin/Cdk complexes such as cyclin D1/Cdk4. Decreased levels of p27Kip1, mainly due to proteosomal degradation, are found in various epithelial tumors originating from lung, breast, colon, ovary, esophagus, thyroid and prostate.Tissue specificity: Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney. |
References |
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1. Exp Mol Med. 2009 Nov 30;41(11):765-71. 2. Int J Gynecol Pathol. 2010 Jan;29(1):8-18. |
Specification |
|
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Aliases | KIP1; MEN4; CDKN4; MEN1B; P27KIP1; CDKN1B |
Entrez GeneID | 1027 |
Swissprot | P46527 |
clone | 3D8 |
WB Predicted band size | 22kDa |
Host/Isotype | Mouse IgG1 |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human |
Immunogen | Purified recombinant fragment of human CDKN1B expressed in E. Coli. |
Formulation | Ascitic fluid containing 0.03% sodium azide. |
Application |
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ELISA | 1/10000 |
Product Image
For Reseach Only
Application Key:WB - Western Blot | IHC - Immunohistochemistry | ICC - Immunocytochemistry | FCM - Flow Cytometry | ELISA - Enzyme-linked Immunosorbent Assay | IP - Immunoprecipitation
#30044

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