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Mouse Monoclonal Antibody to GSK3B
Western blot analysis using GSK3B mouse mAb against A549 (1), K562 (2), PC-12 (3), NIH/3T3 (4), and HEK293 (5) cell lysate.
Mouse Monoclonal Antibody to GSK3B
Western blot analysis using GSK3B mouse mAb against COS7(1),C2C12(2),NIH/3T3(3),C6(4),PC12(5) cell lysate.
Mouse Monoclonal Antibody to GSK3B
Immunofluorescence analysis of NIH/3T3 (left) and U251 (right) cells using GSK3B mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
Mouse Monoclonal Antibody to GSK3B
Flow cytometric analysis of Hela cells using GSK3B mouse mAb (green) and negative control (purple).
Mouse Monoclonal Antibody to GSK3B
Immunohistochemical analysis of paraffin-embedded human lung cancer (left) and breast cancer tissues (right) using GSK3B mouse mAb with DAB staining.
Mouse Monoclonal Antibody to GSK3B
Mouse Monoclonal Antibody to GSK3B
Mouse Monoclonal Antibody to GSK3B
Mouse Monoclonal Antibody to GSK3B
Mouse Monoclonal Antibody to GSK3B

Mouse Monoclonal Antibody to GSK3B

  • 货号:

    30006
  • 别名:

    GSK-3β; GSK3-beta
  • 产品上架时间:

    2024-01-01
  • 应用:

    WB,IHC,IF,FCM
  • 反应种属:

    Human,Mouse,Rat,Monkey
  • 抗体类型:

    Primary antibody
  • Swissprot:

    P49841
  • 规格:

  • 数量:

    -
    +
  • 说明书:

    目录价¥2180

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Mouse Monoclonal Antibody to GSK3B

Description

Glycogen synthase kinase 3 (GSK-3), a serine-threonine kinase with two isoforms (alpha and beta), was originally discovered as a key enzyme in glycogen metabolism. GSK-3 was subsequently shown to function in cell division, proliferation, motility and survival. GSK-3 plays a role in a number of pathological conditions including cancer and diabetes and is increasingly seen as an important component of neurological diseases. GSK-3 phosphorylates tau and presenilin-1, which are involved in the development of Alzheimer's disease. Both isoforms of GSK-3 are ubiquitously expressed, although particularly high levels of GSK-3beta are found in the brain where it is involved in synaptic plasticity, possibly via regulation of NMDA receptor trafficking. GSK-3 phosphorylates over 40 different substrates including signaling proteins, transcription factors and structural proteins, and is part of the signal transduction cascade of a large number of growth factors and cytokines. The activity of GSK is regulated by phosphorylation (Akt: Akt-mediated phosphorylation at Ser21 of GSK-3a and Ser9 of GSK-3

References

1. EMBO J. 1998 Mar 2;17(5):1371-84.

2. Curr Biol. 2001 Jan 9;11(1):44-9.

3. Cancer Lett. 2003 Sep 25;199(2):201-8.

Specification

Aliases GSK-3β; GSK3-beta
Entrez GeneID 2932
Swissprot P49841
clone 3D10
WB Predicted band size 46kDa
Host/Isotype Mouse IgG2a
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human,Mouse,Rat,Monkey
Immunogen Purified recombinant fragment of human GSK3B expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide.

Application

WB 1/500 - 1/2000
IHC 1/200 - 1/1000
IF/ICC 1/200 - 1/1000
FCM 1/200 - 1/400
ELISA 1/10000