Rabbit Monoclonal Antibody to Girdin

This gene encodes a member of the Girdin family of coiled~coil domain containing proteins. The encoded protein is an actin~binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3~kinase (PI3K)~dependent activation of Akt by growth factor receptor tyrosine kinases and G protein~coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]