Rabbit Monoclonal Antibody to Anti~GDF3

This gene encodes a secreted ligand of the TGF~beta (transforming growth factor~beta) superfamily of proteins. Ligands of this family bind various TGF~beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide~linked homodimer. This protein plays a role ocular and skeletal development. Mutations in this gene are associated with microphthalmia, coloboma, and skeletal abnormalities in human patients. [provided by RefSeq, Aug 2016]