Rabbit Monoclonal Antibody to gamma Sarcoglycan

This gene encodes gamma~sarcoglycan, one of several sarcolemmal transmembrane glycoproteins that interact with dystrophin. The dystrophin~glycoprotein complex (DGC) spans the sarcolemma and is comprised of dystrophin, syntrophin, alpha~ and beta~dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Defects in the encoded protein can lead to early onset autosomal recessive muscular dystrophy, in particular limb~girdle muscular dystrophy, type 2C (LGMD2C). [provided by RefSeq, Oct 2008]