Rabbit Monoclonal Antibody to NPTX2

This gene encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C~reactive protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha~amino~3~hydroxy~5~methyl~4~isoxazolepropionic acid (AMPA)~type glutamate receptors at established synapses, resulting in non~apoptotic cell death of dopaminergic nerve cells. Up~regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD. [provided by RefSeq, Feb 2009]