Rabbit Monoclonal Antibody to SIGIRR

Description
Acts as a negative regulator of the Toll~like and IL~1R receptor signaling pathways. Attenuates the recruitment of receptor~proximal signaling components to the TLR4 receptor, probably through an TIR~TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.

Specification
Aliases	TIR8; IL~1R8
Swissprot	Q6IA17
clone	6G7D7
WB Predicted band size	46kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at ~20°C long term. Avoid freeze~thaw cycles.
Species Reactivity	Human, Mouse, Rat
Immunogen	A synthesized peptide derived from it
Formulation	1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Application
WB	1/1000~1/5000