Rabbit Monoclonal Antibody to Proteasome Activator Subunit 4

Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP~ and ubiquitin~independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain~like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C~terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis.