Rabbit Monoclonal Antibody to Frizzled 8

This intronless gene is a member of the frizzled gene family. Members of this family encode seven~transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta~catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine~rich domain of a similar mouse protein has been determined. [provided by RefSeq, Jul 2008]